The link between vitamin D deficiency and fat

Non-alcoholic fatty liver disease (NAFLD) has quietly become one of the most prevalent health problems of our time, yet most people have no idea they are living with this disease. When fat begins to build up silently in the liver, it is often not detected until the damage has already progressed and it is too late. This condition is now a leading cause of cirrhosis, liver failure, and even the need for transplant.

What makes this so dangerous is how easily fatty liver can slip under the radar. You may feel completely fine while your liver is already under severe strain, and by the time symptoms surface, permanent scarring is often present. That’s why it’s so important to understand the root cause and how to reverse the damage before it becomes established.

My research is deeply related to this issue. I am currently in the process of researching liver health in depth and publishing a scientific paper revealing how choline and mitochondrial toxin reduction can help. But another nutrient, vitamin D, is a key factor in determining whether your liver recovers or declines. Vitamin D’s role goes beyond bone health, affecting how the body deals with blood sugar, inflammation, and fat storage.

This opens a new direction for research exploring what happens when vitamin D is optimized in people already suffering from fatty liver disease. The results show how changing this one factor changes the entire trajectory of liver function. This is a discovery that changes the way we think about prevention and recovery.

Vitamin D Supplementation Leads to Measurable Liver Improvements

A study published in Frontiers in Pharmacology pooled results from 16 randomized controlled trials to examine how vitamin D supplementation affected patients with NAFLD.1 By combining data from multiple studies, researchers were able to identify clear trends in how these nutrients affect body composition and key blood markers.

Vitamin D supplementation lowered several risk markers — Across pooled trials, vitamin D supplementation consistently resulted in improvements compared to placebo. People taking vitamin D experienced decreased body weight, body mass index, and waist circumference, indicating changes in fat distribution and metabolic balance.

Additionally, fasting blood sugar levels and HOMA-IR, a measure of insulin resistance, improved, indicating better glycemic control. Liver enzymes also decreased, meaning damage within the liver was less active.

Protective effects reach beyond the liver — Reviews have shown that vitamin D increases HDL cholesterol, the “good” cholesterol that helps remove fat from the bloodstream. This means the benefits extend to heart health, improving liver health while also reducing the load on the cardiovascular system.

In addition to bone health, vitamin D helps regulate blood sugar, calm inflammation, and balance fat metabolism. When levels drop, the liver takes a hit. Inflammation worsens, fat accumulates, and scarring occurs rapidly.2

Consistency was seen across a variety of tests. Although individual studies have produced mixed results, this larger analysis confirms that the benefits are part of a broader pattern rather than an isolated outcome. Improvements were seen regardless of study length or location, with particularly strong effects seen in trials lasting longer than 12 weeks or using higher vitamin D doses.

Overall, this review positions vitamin D as an inexpensive and effective strategy. By addressing weight, blood sugar, cholesterol balance, and liver enzymes all at once, vitamin D has a ripple effect on multiple systems. For people with fatty liver disease, this means that restoring vitamin D status is more than a supportive step and has a direct impact on the disease process.

Vitamin D deficiency is strongly associated with NAFLD severity

A study published in Cureus looked at 100 adults with NAFLD and found that vitamin D deficiency was prevalent and directly linked to how severe the condition became.3 Almost half of the patients (45%) were vitamin D deficient, and another 16% had insufficient vitamin D levels. This means that more than 6 in 10 participants fell below levels considered healthy. This was not an incidental discovery. This emerged as a core feature of NAFLD in our study group.

The more severe the deficiency, the worse the disease. The more severe the vitamin D deficiency, the more advanced liver problems become. Patients with the lowest levels were much more likely to have an enlarged liver, an enlarged spleen, and abdominal fluid accumulation. This condition goes beyond simple fat accumulation and indicates that the liver is progressing to a more serious stage of dysfunction.

Obesity and deficiency overlap — Among overweight participants, 91.7% were vitamin D deficient, compared with 39.1% of normal weight participants. This indicates a strong interaction between excess body fat, vitamin D status, and worsening fatty liver disease.

There was a direct correlation between liver fat and vitamin D. Ultrasound findings showed that patients with more severe fatty liver disease consistently had lower vitamin D levels. The statistical correlation was strong, confirming that the deficiency was not only present in NAFLD patients but was also associated with a noticeable degree of damage inside the liver.

Vitamin D deficiency is associated with insulin resistance. Patients with low vitamin D also had higher levels of insulin resistance, one of the leading causes of NAFLD. This means that deficiency can worsen liver outcomes as well as a wide range of metabolic problems that commonly occur with fatty liver disease, such as diabetes and high blood pressure.

Liver enzymes also reflected the same pattern. People with vitamin D deficiency are more likely to have increased enzymes that signal liver damage. This shows that deficiency is associated not only with structural changes on imaging, but also with active and persistent liver damage.

Taken together, these studies highlight that vitamin D deficiency is a strong predictor of NAFLD severity. Vitamin D deficiency was not an accidental discovery, but was consistently associated with worse liver outcomes, increased metabolic dysfunction, and accelerated disease progression.

How to Address What Actually Causes Liver Dysfunction

If your liver is not working properly, the goal is not just to manage the symptoms, but to eliminate the stressors that caused the damage in the first place. The liver is the body’s central detoxifying organ, and when it becomes overloaded with harmful fats, toxins, or poor nutrition, it has a hard time processing everything else. The following steps target the root cause of liver dysfunction to restore balance and help the body heal from within.

1. Eliminate vegetable oil and alcohol — If you eat packaged foods made from soy, canola, corn, sunflower, or regular “vegetable oils,” your liver is constantly under attack. This oil is high in linoleic acid (LA), a polyunsaturated fat that oxidizes and turns into toxic byproducts that damage the mitochondria, the “engines” of cells.

Alcohol is destructive because it breaks down into substances that damage liver cells. The quickest way to give your liver some breathing room is to cut out all alcohol and vegetable oils right now. When cooking, switch to grass-fed butter, ghee, tallow, or coconut oil.

2. Eat Choline-Rich Foods to Support Liver Health — Think of choline as regulating traffic to the liver. Without it, fat builds up inside liver cells, causing dysfunction and damage. Choline helps pack up fat and move it out, preventing liver blockage. The best food sources are grass-fed egg yolks and grass-fed beef liver. If you skip these foods on a regular basis, your liver is likely not getting the support it needs.

3. Use choline supplements if your diet is deficient — Unless you eat eggs or meat, it is difficult to achieve adequate choline intake from food alone. In this case, supplementation is not an option, but a necessity. Citicoline is one of the most effective forms, and doses between 500 mg and 2,500 mg per day have been shown to help flush fat from the liver while improving brain function. If you’re experiencing signs of brain fog, lack of energy, or fatty liver, this is a simple but powerful action.

4. Recover with sunlight and smart use of vitamin D — Your skin is designed to produce vitamin D from sunlight, and daily exposure to sunlight strengthens your bones and immune system, as well as your liver’s ability to metabolize fat. But here’s the problem. If you are still using vegetable oils, the LA stored in your skin increases your risk of sun damage.

Remove these oils for at least six months before your greatest exposure to sunlight (10 a.m. to 4 p.m.). If you cannot get sunlight, supplement with vitamin D3.4

5. Test and track your vitamin D to stay on target — Instead of guessing, check your vitamin D levels with a simple blood test at least twice a year. Aim for 60 to 80 ng/mL (150 to 200 nmol/L). This product line supports healthy liver function, balanced immunity and energy production. Tests provide a clear starting point and a way to measure progress over time.

Frequently Asked Questions About Fatty Liver and Vitamin D

cue: Why is fatty liver so dangerous if you don’t feel any symptoms?

no way: Fatty liver disease often progresses quietly, with few or no warning signs. By the time symptoms appear, there is likely to already be permanent or advanced damage to the liver. That’s why it’s important to detect it early and address the root cause.

cue: What does vitamin D have to do with liver health?

no way: Vitamin D isn’t just for strong bones. It helps regulate blood sugar, reduce inflammation, and manage how fat is stored and used in the body. Low vitamin D levels can worsen liver damage, accelerating fat accumulation, scarring, and inflammation.

cue: Are fatty liver patients typically deficient in vitamin D?

no way: yes. Studies have shown that vitamin D deficiency is common in people with fatty liver disease, and the more severe the deficiency, the more advanced the liver problem tends to be. In fact, in one study, more than 60% of patients had low vitamin D levels, and those with the lowest levels had the worst liver outcomes.5

cue: Besides vitamin D, what can we do to treat the liver?

no way: The biggest step is to eliminate what is damaging your liver in the first place. Cutting back on vegetable oils and alcohol, adding choline-rich foods like grass-fed egg yolks and grass-fed beef liver, and using sunlight or supplements to restore vitamin D if needed are all powerful ways to reduce the stress on your liver and help it recover.

cue: How do you know if you have enough vitamin D for your liver?

no way: The best way is to test your blood levels twice a year. Aim for a range of 60 to 80 ng/mL (150 to 200 nmol/L). This takes the guesswork out of supporting your liver, metabolism, and overall health.

Test your knowledge with today’s quiz!

Take today’s quiz to see how much you learned from yesterday’s Mercola.com article.

How do egg yolk compounds help prevent osteoporosis and bone loss?

  • Egg yolks contain all the nutrients needed for bone strength, replacing the need for vitamin D.
  • It strengthens bones and lowers the risk of fractures by slowing bone breakdown and stimulating new bone growth.

    Egg yolk compounds soothe bone-destroying cells and activate bone-building cells, helping prevent fractures and keep bones strong as you age. Learn more.

  • It lubricates joints, preventing stiffness and reducing cartilage wear and tear that can cause bone pain or swelling.
  • Egg yolk compounds directly break down damaged bone and rebuild new tissue without the need for external nutrients or sunlight.