Have you ever seen a longer time for small cuts or scraps to heal as you get older? This general experience is associated with changes in cell levels, especially aging cells. These cells stop division and essentially “retire” but simply do not disappear.
For a long time, scientists have believed that most of these retired cells are harmful and contribute to aging and various diseases. But the new research reveals more complex stories. Some aging cells actually help to heal wounds, while other aging cells actually interfere with it.
What is aging cells and why do we have them?
Your body consists of a tank cell that constantly divides and replaces old or damaged cells. This cell division is necessary for growth, recovery and overall health. But cells do not share infinitely. The number of cells divides is often a limit called hayflick limit. Cells reach this limit or if significant damage occurs, it enters the state of cell aging.
This aging cell does not die but stops division. Think like a retired worker. They are no longer produced, but they still affect the environment. At first, scientists saw aging cells mainly harmful. They were related to inflammation and various age -related diseases.
This negative view is from the fact that aging cells release cocktails of aging -related secretion or SASP. SASP is the same as the neighboring communication network. Some messages are helpful as warnings for danger, while other messages do not help as gossip. Similarly, some SASP arguments promote tissue recovery, while other SASPs can cause harmful inflammation.
Some factors make cell aging. These triggers include the activation of the gene that promotes the stress of DNA damage, the stress of harmful molecules (oxidation stress) called free radicals and the cell growth (tumor gene). Certain proteins, such as P21 and P16, play an important role in starting and maintaining these aging conditions.1 This trigger is the same as someone else can retire early. It may be because it is injured, burnout or simply reaching a specific age.
The accumulation of aging cells is closely related to the aging process. As you get older, more and more cells accumulate in your tissues, increasing the decrease in organ function and the risk of age -related diseases. This understanding of aging as a negative process has set up a new stage of research that shows the dual role of these cells in wound healing.
The complex role of aging cells in wound recovery
Although it is often associated with aging and disease, aging cells play a complex role in the body, especially in relation to wound healing. Not all aging cells are the same. For example, they can be classified based on the expression of different proteins such as P16 and P21. The study conducted by the University of Connecticut focused on the distinct roles of the P16-HIGH and P21-HIGH aging cells in the skin wound healing.2
Previously, P16 -high cells played a positive role in this process. However, the role of P21-height cells was not well known. The researchers conducted an experiment on the mouse to selectively remove aging cells of P21-. They found that removing P21-height cells increased about 25%of the wound closure of the female mouse.3 This discovery showed that unlike P16-high cells, P21-high aging cells have a harmful effect on wound healing.
Further surveys show that p21-high cells tend to originate from binding tissues, skin and immune systems, and have inflammatory profiles, suggesting that negative effects on healing may be associated with excessive inflammation.4 This results emphasize the importance of distinguishing different types of aging cells when studying the effects of wound healing and other biological processes.
Negative impact of continuous aging
Some aging cells contribute to early wound recovery, but other elderly cells interfere with healing in chronic wounds that are not healed, especially within a normal period. This type of wound is a common problem for people with diabetes and the elderly.5
The accumulation of aging cells of a particular type contributes to the wound healing delayed in chronic wounds.6 This cell causes continuous inflammation and damages the regeneration of the new tissue, preventing the wound from closing properly.
SASP also plays a role in this negative aspect of aging. Certain SASP factors promote ongoing inflammation, block cell growth, and disassemble out -of -cell matrix. This breakdown is unproductive for appropriate wound closure. In this context, SASP actively interferes with the healing process.
Aging cells play a useful role in the early stages of wound healing, but in the long run, their presence causes significant problems. Think of the wound healing as a carefully adjusted architectural project. In the early stages, the elderly cells act as an experienced project manager, adjusting the arrival of other work crews (other cells) and making the initial repair efficiently.
They perform this by revealing signal molecules (SASP) such as instructions and communication between other teams. However, if these project administrators insist for too long, the instructions are old or unproductive, which interferes with the second stage of construction. This is what happens in chronic wounds.
As mentioned in the review published in the Frontiers of immunology,7 In normal, acute wounds, aging cells appear briefly and are removed by the immune system of the body when the wound is healed. This allows construction projects to proceed smoothly in the second half of the reconstruction and remodeling of the organization.
However, in chronic wounds, these aging cells continue to release SASP signals. This continuous signal transmission leads to chronic inflammatory state, interfering with the normal healing process. This chronic inflammation prevents new and healthy tissues from being properly formed and leads to the destruction of existing tissues. The signal of the SASP also stimulates cells called fiber acids, producing excessive amounts of collagen, the main components of scar tissue.
Collagen’s overproduction leads to fibrosis, which interferes with healing and causes discomfort. This study also emphasizes how the decrease in collagen production and the weaker age -related changes worsens this negative impact on the elderly.
SenologyTics targets elderly cells
Scientists are actively exploring how aging cells are targeted in chronic wounds and other areas of the body. One way is to use a drug called Senolytics. This drug acts like a targeted demolition crew to selectively remove the aging cells with problems.
Another approach focuses on the use of Senomorphics, which acts like a management consultant, to reduce the harmful effects without killing the cells itself.
Feature research suggests that not all aging cells are harmful, but other studies show that natural commercial compounds such as phytin can reduce the burden of elderly cells and expand mortality in certain cases such as Covid-19. I did it.8
Flavonoids, Picetin, are found in fruits and vegetables, especially strawberries and apples. It may be difficult to get treatment with food alone, but adding phytin -containing foods to your diet is one way to promote the healthy balance of elderly cells. Kersetin also acts as a cell decomposition of aging-mediated cancer growth.9
Kersetin is found in many foods, including citrus fruits, green leafy vegetables, broccoli, apple, onions, green tea, red grapes, dark cherry and strawberries, such as blue berry and cranberries. The highest level of these is found in apples, especially onions, broccoli, cherries, strawberries and green tea.
Especially for concentrated sources, consider onion skins. They can have 77 times more Cercetin than the flesh.10 Eating onion peel may not be inappropriate, but consider drinking broth made of onion peel for a more powerful treatment effect.
Kerson is Ginkgo Biloba, St. It is also found in pharmaceutical products such as John’s WORT (Hypericum Performum) and Elderberry (Sambucus Canadensis). If you use Kercetin in the form of a supplement, take the chestnut (with zinc) before going to bed and do not optimize the segmentation characteristics in order not to eat for at least 3-4 hours.
Effect of aging cells for better healing
The study of aging cells revealed complex pictures. This “retired” cell plays a double role in wound healing and other biological functions. Some types of aging cells can help start the healing process, while other types can be extended especially in chronic wounds.
The main takeout is that the context of aging cell activity is important. Understanding this balance is essential for developing effective therapies and reducing early aging. This new understanding of aging cells also opens up the possibility of improving wound healing, especially the elderly who experience delayed healing.
Scientists hope to promote faster and more complete wound closure by targeting certain aging cells. Maintaining a healthy lifestyle is also important for minimizing cell damage and promoting healthy aging. Balanced diets, regular exercise and stress management contribute to reducing the accumulation of harmful aging cells.
In addition, when fat oxidation increases, it interferes with cell metabolism, accelerating aging and developing age -related diseases. When you move to burn fat in the glucose where the body burns, an imbalance occurs, resulting in accumulation of harmful molecules such as reducing stress and reactive oxygen species.
This metabolic movement interferes with cell function and pushes the cell into aging. Reducing the intake of linoleic acid (LA), a common multi -unsaturated fatty acid found in many seed oils, will help to maintain metabolic balance and prevent cell damage.
The main way to do this is to avoid processed foods. Most of them contain seed oil. Maintaining information about the latest discovery during the research in this field, you can make a choice based on your health.
