Targeting vitamin D pathways helps to treat wounds and keloids.

• A new perspective of keloid treatment- A recent study published in Burns & Trauma Journal conducted by researchers at the University of Cincinnati.³ In keloid cells, we found that the enzyme called CYP24A1, which is an excessive activity, quickly disassembled vitamin D before supporting wound healing. This means that even if someone has a normal vitamin D level, the skin cannot be used properly, so that excessive scars are not confirmed.

• Inhibiting this height enzyme can help to restore the beneficial effects of vitamin D. This helps to reduce excessive scars and improve skin repair.⁴ According to an article from news-Medical.net:

“The current treatment shows a limited efficacy due to the imperfect understanding of the molecular process behind the keloid formation, and the patient has almost reliable options. In solving this difference, this study is deeply digging into the molecular dynamics of keloid pathology and identifying potential goals for more effective arbitration. ”⁵

• Kelloid cells overexpression CYP24A. This study analyzed kelloid derived keratinocytes (cells responsible for skin regeneration) and compared them with normal skin cells. The results showed that keloid cells had a very high level of CYP24A1, which was inefficient for vitamin D to control inflammation and fibrosis.

• CYP24A1 blocking restores the benefits of vitamin D. Then it is more effective in adjusting scars by testing whether the CYP24A1 can activate vitamin D longer. When they suppressed this enzyme, the expression of genes associated with excessive scars, such as Perry Austin and Hyalurul, was significantly reduced.⁶

• CYP24A1 blocking blocking collagen- Collagen is a protein that gives the skin a structure, but in keloids, it accumulates thick and disorders to create a hard scar. The researchers have found that the CYP24A1 blocking returns collagen production into a more balanced state, so that keloid tissue can act like a normal skin.⁷

• Kersetin can help. But this study emphasized that even an individual with sufficient vitamin D can still have a functional deficiency in the skin.

Kelloid cells disassemble vitamin D so quickly that standard supplements may not be enough to solve problems. This explains why oral or local vitamin D is not effective in treating keloids.⁸ In this case, taking natural CYP24A1 inhibitors such as Kersetin can be performed.

• Blocking CYP24A1 reduces inflammation. Kelloid scars are characterized by persistent inflammation, which causes continuous growth even after the initial wounds are healed. However, when researchers blocked CYP24A1, the inflammatory cytokine levels of protein that promoted swelling and tissue damage fell. This suggests that when vitamin D is activated properly, it can soothe chronic inflammation and prevent keloid progression.⁹

• Vitamin D adjusts fibroblasts. Fiber cells are cells that produce other structural components of collagen and skin. In general, fibroblasts respond to injuries by creating new tissues to close wounds. But in the keloid scars, these cells cannot stop the proper signal, causing excessive growth.

This study found that blocking the CYP24A1 can help vitamin D inhibits over -active fiber cells and restores normal healing reactions. This means that instead of generating scarring endlessly, the skin can be healed in a controlled and organized manner.¹⁰

• These results emphasize the new method of approaching keloid treatment. Instead of simply trying to remove the keloid surgically, the approach that often leads to recurrence can target the enzyme that interferes with the skin healing to prevent the problem of roots.

“(O) The results suggest that vitamin D treatment and CYP24A1 inhibitors should be further explored as potential treatment or therapeutic assistance for suppressing keloid development and growth.” The research author concluded.¹¹

• Effect of Vitamin D against ChloAsma- The participants included 480 men and women between 18 and 65 years of age, and all of them had a skin condition marked with irregular pigmentation. They were randomly assigned to two groups. One received local and oral vitamin D3 (5,000 to 10,000 IU/Sun) and the other was plenty of placebo.

• Vitamin D has a notable advantage for skin health. Researchers measured changes in wound size and skin hydration levels. Over six months, the vitamin D group showed significant improvements in all these areas compared to the placebo group.¹³

• The most amazing result was the speed of wound healing. Participants taking vitamin D in the sixth week were 70.2% less than 30.8% of the placebo group. It is more than twice the healing speed. Until the second week, vitamin D group decreased by 25.2%, and placebo groups lag behind 10.7%.¹⁴

• Effect of vitamin D on skin hydration- In the vitamin D group, the level of skin hydration has also been greatly improved. When the study began, both groups had an average of 35 hydration in the hydration scale. Up to week 6, the average hydration score for people taking vitamin D is 42.5, while the placebo group has been stagnant at 35.5.

Dewded skin is especially important for individuals who are having difficulty in chronic skin because cracks, stimuli and recovery are easy.¹⁵

• This study also measured the target of the participant’s water loss (TEWL). This evaluates how many water is escaped from the skin surface. Low TEWL levels improve skin barrier function. The TEWL level of vitamin D group dropped from 10.5 to 8.5 from the baseline until the sixth week. In contrast, the level of placebo groups did not show meaningful improvements and maintained more than 10 throughout the research.¹⁶

“Our research has provided additional support for the expansion of evidence that vitamin D plays an important role in skin health, especially chloresma treatment and wound recovery.

In order to comprehensively understand and maximize the application of dermatology, further investigations are required, but vitamin D provides auspicious paths for the upcoming treatment intervention. ” Researchers concluded.¹⁷

• Skin problems may be related to vitamin D. If you are struggling with slow healing, persistent scars or keloids, it is time for the body to look at the ability to use vitamin D effectively. As you can see from the skin that is easy to develop keloids, if your body fails to get vitamin D too fast, you won’t get an advantage even if you take supplements.

• The key is to optimize how the body gets and processes vitamin D. I think it’s the best way to optimize the level of this nutrient every day, but you need to do it at an appropriate time and know a particular warning.

• One of the important factors to consider is diet. If you eat a processed food diet with a lot of vegetable oils with linoleic acid (LA), you can ride in the sun and damage your skin. This is because when ultraviolet rays encounter the skin, it interacts with LA, causing inflammatory reactions and DNA damage.

• Remove LA from the body to alleviate this problem. In the meantime, avoid high intensity noon until you take off the seed oil for at least six months. Go out early in the morning or late afternoon. If you don’t completely remove LA in your diet, but you have to go out at noon, there are several protection measures you can try.

• Remember this simple safety test when exposed to the sun. To see the first signs of pink (early warning of the sun), you can see the skin and stop before preventing damage before the skin turns pink. This helps to determine the safe exposure time.