Why precision fermentation will power the future of food innovation

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America’s insatiable demand for protein is putting renewed focus on precision fermentation. This technology has been around for decades, but is now being considered as a potential solution for scaling up production of high-value ingredients.

Precision fermentation essentially turns microorganisms like yeast into mini-factories, programming them to produce ingredients like palm oil and proteins. For example, in the cheese industry, this technology is widely used to produce rennet, a key ingredient found in the stomach of young calves.

Recently, as precision fermentation capabilities have expanded, some startups are promoting this technology as a method of manufacturing natural food dyes. As material costs rise due to climate change and other issues, this technology offers a promising, less environmentally intensive solution to expand food production inexpensively.

With over 30 years of experience in precision fermentation, Cargill operates a fermentation network that includes more than $2 billion invested across infrastructure and partnerships. In a conversation with Food Dive, Florian Schattenmann, Cargill’s Chief Technology Officer and Vice President of Innovation and R&D, talks about what precision fermentation is and how it could redefine the future of food innovation.

This conversation has been edited for clarity.

Food Dive: What is Precision Fermentation? Is it similar to farmed or lab-grown meat, or is it something different?

Florian Schattenmann, Cargill Chief Technology Officer and Vice President of Innovation and R&D

Provided by Cargill

Florian Schattenmann: I’ve also heard a lot about cultivated meat, but it’s actually not an accurate term for cultivated meat. Cultivated meat basically does what the body does. Not just inside the body or inside the tank. So what I mean is, if you feed that cell, it will partially grow, so you get more cells. And they do so in a controlled environment.

Precision fermentation is a little different. What’s there is an organism. It could be bacteria. It could be mold. It could be yeast. And these organisms take a substrate, something they “eat”, and then digest it and spit something out.

This is actually a digestive process inside the cell. For example, each of these tiny yeast cells can be used to digest incoming glucose, a common sugar, into the desired target molecule.

There are a few categories where this works really well. The first is the sweetness aspect, which we’re driven by. Next is protein, which is kind of the next big wave. And perhaps the furthest third factor is how to use it to make certain special oils.

I am from Bavaria. We have been making beer through fermentation for thousands of years. The yeast that was originally there is filtered out when you drink the beer. So, in principle, precision fermentation is not much different. This is a more specific process and therefore more accurate.

Please tell us more about the advantages of precision fermentation. How are they set to hinder food innovation?

There are some really big benefits to this. Because if you can train yeast very specifically, you can get relatively high yields.

Second, you can do this in an environment that doesn’t use as much water or energy as alternatives. We performed the comparison to obtain virtually identical target molecules. Precision fermentation saves over 90% of water and energy compared to growing it somewhere, extracting it, and doing everything else.

But there is also a food security element to this. Because whatever you want, you can make it right there. There is also price stability.

And finally, and perhaps a little unusually, is that these organisms can be trained to become more capable. Actually, you can make it a bit more specific. For example, if you have a dairy protein and are concerned about allergens, you can determine whether that protein produces the desired key parts in high yield. So you have some control over the final piece.